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Xenotransplantation of goat ovary as an alternative to analyze follicles after vitrification.

The aim of this study was to evaluate the caprine preantral follicles enclosed on vitrified/warmed ovarian cortex grafted to nude BALB/ mice during one month. The ovarian cortex from goats was fragmented (3 × 3 × 0.5 mm) and divided into four groups: fresh control, vitrified control, fresh transplant and vitrified transplant. Follicular morphology, development and density, Fibrosis as well as apoptosis, and tissue revascularization were evaluated. It was also observed a significant decrease of morphologically normal preantral (primordial, transition, primary and secondary) follicles in both vitrified control and vitrified transplant treatments when compared with both fresh control and fresh transplant. However, fresh control and fresh transplant exhibited a similar percentage of developing follicles. Additionally, Vitrified control showed a significant increase of developing follicles in comparison with both fresh control and fresh transplant. Follicular density significantly decreased in all treatments in comparison with fresh control. We observed high fibrosis in both fresh and vitrified transplant. The mRNA expression of caspase 3 was lower in both fresh and vitrified transplant in comparison with vitrified control. In conclusion, xenotransplantation is an excellent strategy to maintain normal preantral follicles morphology after vitrification/warming of goat ovarian tissue. However, in order to ensure the survival and development of these follicles, it is essential to improve the revascularization of the graft. This article is protected by copyright. All rights reserved.

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