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JOURNAL ARTICLE
REVIEW
Bile acid homeostasis in gastrointestinal and metabolic complications of cystic fibrosis.
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society 2018 September 8
With the improved treatment of the pulmonary complications of cystic fibrosis (CF), gastrointestinal problems have become more important in the morbidity in CF. A hallmark of the gastrointestinal phenotype of CF, apart from pancreatic insufficiency, is a disruption of bile acid homeostasis. Bile acid homeostasis is important for many gastrointestinal processes including fat absorption, inflammation, microbial composition, as well as regulation of whole body energy metabolism. This review describes the impairment of bile acid homeostasis in CF, its possible consequences for gastrointestinal and metabolic complications and its potential as a target for therapy.
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