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Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells.

Fabrizio Simeoni, Tim C P Somervaille
Cell Stem Cell 2018 September 7
Myelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2.

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