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The relationship between Toxocara species seropositivity and allergic skin disorders: a systematic review and meta-analysis.
We performed a systematic review and meta-analysis on observational studies to evaluate the possible associations between Toxocara species seropositivity and allergic skin disorders (ASDs). We searched the MEDLINE, ScienceDirect, Scopus, Web of Science and Google Scholar databases to 15 May 2018 to identify the relevant studies. We used a random effects meta-analysis model to generate the pooled odds ratio (OR) and 95% confidence intervals (CIs). Fifteen studies, including eight studies with a case-control design (735 patients and 1342 controls) and seven studies with a cross-sectional design (a total of 4804 participants, 1302 individuals with ASDs and 3502 without ASDs), were included in the meta-analysis. We found an increased risk for ASDs in individuals with Toxocara seropositivity (OR 1.75 [95% CI 1.16 to 2.64]). Subanalysis showed that Toxocara seropositivity was significantly associated with urticaria (OR 2.97 [95% CI 1.53 to 5.76]), however, it was not significantly associated with atopy (OR 1.08 [95% CI 0.55 to 2.15]) and eczema (OR 1.62 [95% CI 0.95 to 2.78]). Moreover, the pooled ORs were 2.34 (95% CI 1.32 to 4.15) and 1.27 (95% CI 0.69 to 2.35) for case-control and cross-sectional studies, respectively. The results of our study support hypotheses regarding the existence of a positive relationship between Toxocara infection and allergic disorders, although this association should be further investigated by longitudinal and mechanism studies.
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