We have located links that may give you full text access.
Intracellular Ca 2+ mobilization pathway via bradykinin B 1 receptor activation in rat trigeminal ganglion neurons.
Journal of Physiological Sciences : JPS 2018 September 5
Bradykinin (BK) and its receptors, B1 and B2 , in trigeminal ganglion (TG) neurons are involved in the regulation of pain. Recent studies have revealed that B1 receptors are expressed in neonatal rat TG neurons; however, the intracellular signaling pathway following B1 receptor activation remains to be elucidated. To investigate the mechanism by which B1 receptor activation leads to intracellular Ca2+ mobilization, we measured the intracellular free Ca2+ concentration ([Ca2+ ]i ) in primary-cultured TG neurons. The application of Lys-[Des-Arg9 ]BK (B1 receptor agonist) increased the [Ca2+ ]i in these TG neurons even in the absence of extracellular Ca2+ . Pretreatment with inhibitors of ryanodine receptors or sarco/endoplasmic reticulum Ca2+ -ATPase suppressed the increase in Lys-[Des-Arg9 ]BK-induced [Ca2+ ]i . The Lys-[Des-Arg9 ]BK-induced [Ca2+ ]i increase was unaffected by phospholipase-C inhibitor. B1 receptor activation-induced [Ca2+ ]i increase was suppressed by phosphodiesterase inhibitor and enhanced by adenylyl cyclase inhibitor. These results suggest that B1 receptor activation suppresses intracellular cAMP production via adenylyl cyclase inhibition and mobilizes intracellular Ca2+ via ryanodine receptors that access intracellular Ca2+ stores.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app