We have located links that may give you full text access.
Assessment of superficial retinal microvascular density in healthy myopia.
International Ophthalmology 2018 September 4
PURPOSE: To evaluate retinal microvasculature in healthy myopia and investigate the correlation between microvascular density and ocular factors.
METHODS: A total of 174 eyes from 174 healthy Korean subjects were included. The eyes were divided into four groups according to refraction: emmetropia [21 eyes, - 1.00 D ≤ mean spherical equivalent (MSE) < + 0.75 D], mild myopia (32 eyes, - 3.00 D ≤ MSE < - 1.00 D), moderate myopia (76 eyes, - 6.00 D ≤ MSE < - 3.00 D), and high myopia (45 eyes, MSE < - 6.00 D). Images of retinal vasculature in parapapillary and parafoveal area were obtained using optical coherence tomography angiography. Superficial retinal microvascular density was measured for correlation analysis with ocular parameters.
RESULTS: High myopia was found to have a lower superficial parapapillary microvascular density compared with the other groups in total parapapillary area, and in sectors of nasal and inferonasal (all p ≤ 0.001). The superficial parapapillary microvascular density showed a negative correlation with axial length (AL) and intraocular pressure (IOP) (β = - 0.479, p = 0.008 and β = - 0.160, p = 0.048, respectively), and a positive correlation with parapapillary retinal nerve fiber layer (RNFL) thickness (β = 0.140, p < 0.001). However, there was no significant difference in superficial parafoveal microvascular density among all groups (p > 0.05).
CONCLUSIONS: This study reveals that superficial parapapillary microvascular density is lower in high myopia and has correlation with AL, IOP, and parapapillary RNFL thickness. It also indicates that superficial parafoveal microvascular density tends to be unaffected by healthy myopia. These retinal microvascular alterations may facilitate understanding the pathogenesis of glaucomatous optic nerve damage in high myopia.
METHODS: A total of 174 eyes from 174 healthy Korean subjects were included. The eyes were divided into four groups according to refraction: emmetropia [21 eyes, - 1.00 D ≤ mean spherical equivalent (MSE) < + 0.75 D], mild myopia (32 eyes, - 3.00 D ≤ MSE < - 1.00 D), moderate myopia (76 eyes, - 6.00 D ≤ MSE < - 3.00 D), and high myopia (45 eyes, MSE < - 6.00 D). Images of retinal vasculature in parapapillary and parafoveal area were obtained using optical coherence tomography angiography. Superficial retinal microvascular density was measured for correlation analysis with ocular parameters.
RESULTS: High myopia was found to have a lower superficial parapapillary microvascular density compared with the other groups in total parapapillary area, and in sectors of nasal and inferonasal (all p ≤ 0.001). The superficial parapapillary microvascular density showed a negative correlation with axial length (AL) and intraocular pressure (IOP) (β = - 0.479, p = 0.008 and β = - 0.160, p = 0.048, respectively), and a positive correlation with parapapillary retinal nerve fiber layer (RNFL) thickness (β = 0.140, p < 0.001). However, there was no significant difference in superficial parafoveal microvascular density among all groups (p > 0.05).
CONCLUSIONS: This study reveals that superficial parapapillary microvascular density is lower in high myopia and has correlation with AL, IOP, and parapapillary RNFL thickness. It also indicates that superficial parafoveal microvascular density tends to be unaffected by healthy myopia. These retinal microvascular alterations may facilitate understanding the pathogenesis of glaucomatous optic nerve damage in high myopia.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app