We have located links that may give you full text access.
Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum.
Clinical & Experimental Ophthalmology 2018 August 32
IMPORTANCE: The diagnostic accuracy of different retinal imaging modalities to detect active choroidal neovascularization (CNV) in pseudoxanthoma elasticum (PXE) is essential to enable a correct diagnosis but currently poorly understood.
BACKGROUND: Optical coherence tomography (OCT), fluorescein angiography (FA) and optical coherence tomography angiography (OCT-A) are employed in daily practice but a systematic comparison of these imaging techniques is lacking.
DESIGN: Retrospective, observational study.
PARTICIPANTS: Twenty patients (31 eyes) with PXE.
METHODS: OCT, FA and OCT-A imaging was performed in each eye and graded separately by independent readers.
MAIN OUTCOME MEASURES: Diagnostic accuracy, sensitivity and specificity to detect CNVs of each modality and longitudinal change of CNV size measured by OCT-A.
RESULTS: OCT showed the highest diagnostic accuracy (kappa=0.57) in comparison to OCT-A or FA (kappa=0.39 and 0.37, respectively). OCT-A, OCT and FA showed a diagnostic sensitivity of 0.9, 0.85 and 0.6, and a diagnostic specificity of 0.45, 0.72 and 0.82, respectively. Evaluation of longitudinal OCT recordings (24 eyes) resulted in optimal sensitivity and specificity (kappa=1.0). Although median CNV size assessed using OCT-A remained stable on longitudinal measures of 7 eyes, two eyes showed a distinct increase over time despite anti-VEGF treatment.
CONCLUSIONS AND RELEVANCE: The systematic use of OCT, FA and OCT-A imaging can facilitate the diagnostic accuracy for detection and follow-up of CNV activity in PXE. While structural OCT is of high value, especially when longitudinal follow-up images are available, FA and OCT-A data might contribute to diagnostic accuracy in more complex cases. This article is protected by copyright. All rights reserved.
BACKGROUND: Optical coherence tomography (OCT), fluorescein angiography (FA) and optical coherence tomography angiography (OCT-A) are employed in daily practice but a systematic comparison of these imaging techniques is lacking.
DESIGN: Retrospective, observational study.
PARTICIPANTS: Twenty patients (31 eyes) with PXE.
METHODS: OCT, FA and OCT-A imaging was performed in each eye and graded separately by independent readers.
MAIN OUTCOME MEASURES: Diagnostic accuracy, sensitivity and specificity to detect CNVs of each modality and longitudinal change of CNV size measured by OCT-A.
RESULTS: OCT showed the highest diagnostic accuracy (kappa=0.57) in comparison to OCT-A or FA (kappa=0.39 and 0.37, respectively). OCT-A, OCT and FA showed a diagnostic sensitivity of 0.9, 0.85 and 0.6, and a diagnostic specificity of 0.45, 0.72 and 0.82, respectively. Evaluation of longitudinal OCT recordings (24 eyes) resulted in optimal sensitivity and specificity (kappa=1.0). Although median CNV size assessed using OCT-A remained stable on longitudinal measures of 7 eyes, two eyes showed a distinct increase over time despite anti-VEGF treatment.
CONCLUSIONS AND RELEVANCE: The systematic use of OCT, FA and OCT-A imaging can facilitate the diagnostic accuracy for detection and follow-up of CNV activity in PXE. While structural OCT is of high value, especially when longitudinal follow-up images are available, FA and OCT-A data might contribute to diagnostic accuracy in more complex cases. This article is protected by copyright. All rights reserved.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app