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Effects of low phosphorus intake on serum calcium, phosphorus, alkaline phosphatase activity and parathyroid hormone in growing dogs.
Journal of Animal Physiology and Animal Nutrition 2018 August 26
A sufficient and balanced supply of calcium and phosphorus is important mainly for the skeletal health of dogs, especially during growth. Numerous reports and research results are quoted, which focus mainly on the effects of both deficient or excessive calcium supplies. The important role that phosphorus plays in the disruption to skeletal development is also explored. The aims of this study were to evaluate the effects of a low phosphorus supply on selected serum parameters of calcium and phosphorus metabolism in both medium and large breed growing dogs, alongside the effects on the apparent digestibility and retention of these minerals as well as the musculoskeletal development, which were published before. Beagle and Foxhound-crossbred puppies (n = 53) between the age of 6 and 24 weeks were either fed a balanced (control) or a low phosphorus diet, the latter one providing about one-third of P amount fed to the control group. In regular intervals, blood samples were obtained to measure serum levels of phosphorus, calcium, alkaline phosphatase activity (ALP) and parathyroid hormone (PTH). Functional Additive Mixed Models were used to analyse these serum concentrations per group and per diet. In the puppies being fed the low phosphorus diet, a distinct decline of serum phosphate concentration was detected with a more pronounced and prolonged effect in the smaller Beagles. At the same time, serum calcium concentration altered in the opposite direction, implying that the product of calcium multiplied by phosphorus was regulated more closely than the calcium to phosphorus ratio. The PTH concentrations were reduced and ALP activity increased at certain time points during the low phosphorus feeding compared to the puppies being fed the control diet. In the latter group, an effect of time or maturation could be demonstrated in relation to the serum phosphate concentration.
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