Quadrupole mass filter operation with dipole direct current and quadrupole radiofrequency excitation.

RATIONALE: For mass analysis, a quadrupole mass filter (QMF) usually operates at the upper tip of the first stability region. We introduce a new mode of QMF operation with dipole direct current (dc) and with auxiliary quadrupole excitation. Before experimental investigation of this mode, we have carried out numerical simulations of this process.

METHODS: Based on the analytical description of the equations of ion motion and mapping of stability islands, ion trajectory calculations are used to calculate peak shapes or mass filter transmission contours. Ions are given Gaussian distributions of initial positions in x and y, and thermal initial velocity distributions. The effects of the dipole dc in the y direction and auxiliary quadrupole excitation in the x and y directions are modeled.

RESULTS: We find that, with dipole dc excitation, the working area of the first stability region decreases and a new y stability boundary follows a βy line. This allows control of the resolution with the removal of the low-mass tail of a peak thereby improving the isotopic abundance sensitivity by about two orders of magnitude. The operation of a QMF with high resolution (about 5000) and high transmission (20-25%) and with a relatively short sorting time of ions n = 150 radiofrequency (rf) cycles based on the use of dipole dc and quadrupole excitation is shown.

CONCLUSIONS: A new mode of QMF operation with dipole direct current (dc) and with an auxiliary quadrupole is discussed. Using dc excitation allows control of the resolution with the removal of the low-mass tail of a peak. The method of operation of a quadrupole mass filter with high resolution (about 5000) and high transmission (20-25%) and a relatively short sorting time (150 rf cycles) based on the use of dipole dc and on quadrupole excitation is shown.