Tempering Madness: Emil Kraepelin’s Research on Affective Disorders.

This essay examines some of the research practices and strategies that the German psychiatrist Emil Kraepelin (1856–1926) deployed in his efforts to account for the significance of emotions in psychiatric illnesses. After briefly surveying Kraepelin’s understanding of emotions and providing some historical context for his work in the late nineteenth century, it examines three different approaches that he took to studying emotions. First, it discusses his work in experimental psychology and his use of so-called artificial insanity to study affective disorders. It then turns to his clinical research, exploring his particular interest in the course and outcome of psychiatric disorders and then showing how those concerns related to his nosological delineation of manic depressive illness. Finally, it considers briefly how he attempted to expand his “clinical gaze,” turning it outward onto larger, nonhospitalized populations in an attempt to study subclinical forms of affect or temperaments. The article argues that the inadequacies and limitations of his own experimental and clinical research practices contributed to his evolving understanding of affective disorders. In particular, they led him to expand and differentiate his understanding of manic-depressive illness so as to take greater account of premorbid symptoms or temperaments.