We have located links that may give you full text access.
Methods for Handling Left-Censored Data in Quantitative Microbial Risk Assessment.
Applied and Environmental Microbiology 2018 August 18
Data below detection limits, left-censored data, are common in environmental microbiology, and decisions in handling censored data may have implications for quantitative microbial risk assessment (QMRA). In this paper, we utilize simulated data sets informed by real-world enterovirus water data to evaluate methods for handling left-censored data. Data sets were simulated with four censoring degrees (low (10%), medium (35%), high (65%), and severe (90%)) and one real life censoring example (97%) and were informed by enterovirus data assuming a lognormal distribution with a 2.3 genome copies/L limit of detection (LOD). For each data set, 5 methods for handling left-censored data were applied: 1) Substitution with LOD/√2, 2) Lognormal maximum likelihood estimation (MLE) to estimate mean and standard deviation, 3) Kaplan-Meier estimates (KM), 4) Imputation method using MLE to estimate distribution parameters (MI Method 1), 5) Imputing from a uniform distribution (MI Method 2). Each data set mean was used to estimate enterovirus dose and infection risk. Root mean square error (RMSE) and bias were used to compare estimated and known doses and infection risks. MI Method 1 resulted in lowest dose and infection risk RMSE and bias ranges for most censoring degrees, predicting infection risks at most 1.17 x 10-2 from known values under 97% censoring. MI Method 2 was the next overall best method. For medium to severe censoring, MI Method 1 may result in the least error. If unsure of the distribution, MI Method 2 may be a preferred method to avoid distribution misspecification. IMPORTANCE This study evaluates methods for handling low (10%) to severe (90%) left-censored data within an environmental microbiology context, and demonstrates that some of these methods may be appropriate when using data containing concentrations below a limit of detection to estimate infection risks. Additionally, this study uses a skewed data set, which is an issue typically faced by environmental microbiologists.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app