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Sex and Long-Term Outcomes After Implantation of Absorb Bioresorbable Vascular Scaffold for Treatment of Coronary Artery Disease.
EuroIntervention 2018 August 15
AIMS: Women and men suffering of coronary artery disease differ in their risk profile. We sought to investigate the impact of sex on 2-year outcomes after BVS implantation in routine clinical practice.
METHODS AND RESULTS: Sex-based analysis of clinical outcomes was done by pooling the individual patient data of ISAR-ABSORB and KUM-ABSORB registries performed in 4 high-volume tertiary centers in Munich. Of the total of 1032 patients, 259 (25.1%) were women. The primary composite endpoint of death, target-vessel myocardial infarction (TV-MI) and target lesion revascularization (TLR) through 2 years occurred in 13.2% of women and 17.9% of men (p = 0.12). Compared to men, women experienced numerically lower rates of TLR and definite or probable BVS thrombosis - 7.5% vs. 12.4% (p=0.051) and 1.2% and 2.7% (p=0.20), respectively. Independent predictors of increased risk for TLR were use of smaller size BVS (HR 1.28, 95% CI 1.02-1.62), while being women was a protective factor (HR 0.59, 95% CI 0.35-1.00).
CONCLUSIONS: BVS used in routine setting tends to perform better among women compared to men, which might be partially related to their lower complexity of coronary artery disease.
METHODS AND RESULTS: Sex-based analysis of clinical outcomes was done by pooling the individual patient data of ISAR-ABSORB and KUM-ABSORB registries performed in 4 high-volume tertiary centers in Munich. Of the total of 1032 patients, 259 (25.1%) were women. The primary composite endpoint of death, target-vessel myocardial infarction (TV-MI) and target lesion revascularization (TLR) through 2 years occurred in 13.2% of women and 17.9% of men (p = 0.12). Compared to men, women experienced numerically lower rates of TLR and definite or probable BVS thrombosis - 7.5% vs. 12.4% (p=0.051) and 1.2% and 2.7% (p=0.20), respectively. Independent predictors of increased risk for TLR were use of smaller size BVS (HR 1.28, 95% CI 1.02-1.62), while being women was a protective factor (HR 0.59, 95% CI 0.35-1.00).
CONCLUSIONS: BVS used in routine setting tends to perform better among women compared to men, which might be partially related to their lower complexity of coronary artery disease.
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