We have located links that may give you full text access.
Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
Neuropsychopharmacology Reports 2018 June
BACKGROUND: In the vertebrate central nervous system as well as in the periphery, serotonin, also known as 5-hydroxytriptamine (5-HT), function as a neurotransmitter, a hormone or a mitogen. 5-HT receptors are composed of 7 family 5-HT1-7 receptors, comprising of 14 structurally and pharmacologically distinct 5-HT receptor subtypes. Previous experimental studies showed that mouse 5-HT1A , 5-HT4 and 5-HT7 receptors are regulated by post-translational protein palmitoylation, the reversible attachment of the lipid palmitate to intracellular cysteine residues. Here, we further focused on conservation of these putative palmitoylation sites found in vertebrate 5-HT receptor orthologs.
METHODS AND RESULTS: Analysis of sequence databases provides evidence to suggest that palmitoylation sites of these 5-HT receptors have been extremely conserved in the vertebrate lineages from jawless fishes to human, in spite of the divergence of 5-HT1A , 5-HT4 or 5-HT7 receptors full-length amino acid sequences during molecular evolution.
CONCLUSION: Our findings mean that dynamic regulation of 5-HT receptors made possible by reversible post-translational protein palmitoylation may be critical for refined functions of the vertebrate serotonergic systems.
METHODS AND RESULTS: Analysis of sequence databases provides evidence to suggest that palmitoylation sites of these 5-HT receptors have been extremely conserved in the vertebrate lineages from jawless fishes to human, in spite of the divergence of 5-HT1A , 5-HT4 or 5-HT7 receptors full-length amino acid sequences during molecular evolution.
CONCLUSION: Our findings mean that dynamic regulation of 5-HT receptors made possible by reversible post-translational protein palmitoylation may be critical for refined functions of the vertebrate serotonergic systems.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app