Protection of manganese oxide nanoparticles-induced liver and kidney damage by vitamin D.

Metal nanoparticles (NPs) have been extensively used in industry as well as in biomedical application. Manganese oxide-nanoparticles (MnO2 -NPs) one of these materials, have many applications. This study was designed to evaluate the protective role of vitamin D against MnO2 -NPs -induced toxicity in the BALB c mice. These mice were randomly assigned to 4 (n = 10). In this study, MnO2 -NPs (10 mg/kg), vitamin D (10 mg/kg) and MnO2 -NPs plus vitamin D were administered interperitoneally once daily for 50 consecutive days. The liver and kidney functions, the levels of serum glucose, albumin (ALB), bilirubin (BIL) and total protein were studied. The results indicated that MnO2 -NPs administration significantly decreased liver and kidney functions, and increased glucose and bilirubin serum levels compared to control group (P < 0.05). However, vitamin D administration significantly boosted liver and kidney functions, decreased glucose and bilirubin serum level compared to the group received MnO2 -NPs (P < 0.05). It seems that vitamin D administration could protect the liver and kidney damage induced by MnO2 -NPs. Probably, given the use of these nanoparticles as a contest agent in humans, having normal levels of vitamin D or receiving it at the time of the test can inhibit liver and kidney toxicity induced by MnO2 -NPs.