Phytoconstituents and their possible mechanistic profile for Alzheimer's Disease - A Literature Review.

As the global aged population is increasing tremendously, time has come to concentrate on tail end life stage diseases. Alzheimer's disease (AD) is one such disease whose origin is an enigmatic, impacts later stage of life drastically due to irreparable damage of cognition. The characteristic feature of the disease is the accumulation of neurotoxic amyloid-beta (Aβ) and hyper phosphorylated Tau protein as fibrillary tangles. Several research reports obtained from in vitro and in vivo studies proved the efficacy of herbals in culminating neurodegenerative changes of AD by acting through various molecular pathways at various stages. So far some AChE inhibitors and NMDA receptor antagonists are the only approved medications and moreover western medicine is concentrating in isolation of moieties from the extracts that are responsible for therapeutic action. Even though several herbals have shown neuroprotective actions, we have mentioned about the phytoconstituents that have been tested experimentally against different Alzheimer's pathology models.