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Journal Article
Review
Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application.
Cell Chemical Biology 2018 November 16
We present a perspective of our view of the application of cryoelectron microscopy (cryo-EM) to structure-based drug design (SBDD). We discuss the basic needs and requirements for SBDD, the current state of cryo-EM, and the challenges that need to be overcome for this technique to reach its full potential in facilitating the process of drug discovery.
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