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Viperin Poisons Viral Replication.

Lisa F P Ng, Julian A Hiscox
Cell Host & Microbe 2018 August 9
Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design.

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