Silane coatings of metallic biomaterials for biomedical implants: A preliminary review.

In response to increased attention in literature, this work provides a qualitative review surrounding the application of silane-based coatings of metallic biomaterials for biomedical implants. Included herein is both a brief summary of existing knowledge and concepts regarding silane-based thin films, along with an analysis of recent peer-reviewed publications and advances towards their practical application for biomedical coatings. Specifically, the review identifies innovative silane-based coatings according to their molecular identity and film structure and analyses their impact on the biocorrosion resistance, protein adsorption, cell viability, and antimicrobial properties of the overall coated implant. It is shown that a range of common silanes clearly exhibit promising properties for biomedical implant coatings, but further work is needed, particularly on mechanisms of physiological interaction and characteristic effects of silane functional groups, before seeing clinical use. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2901-2918, 2018.