Critical Micrornas in Lung Cancer: Recent Advances and Potential Applications.

BACKGROUND: MicroRNAs (miRNAs) play an important role in regulation of various genes involved in cell growth, development and the maintenance of body homeostasis. They are closely linked to different human diseases, in particularly in cancers. Amplification and overexpression of some miRNAs that called 'oncomiRs' or down-regulation of tumor suppressor miRNAs are associated with genetic alterations that are sufficient to drive tumorigenesis in humans. Lung cancer is the leading cause of cancer related deaths worldwide. High mortality rate of lung cancer is not changed even with recent advances in cancer treatment. Several studies demonstrated that miRNAs are involved in the pathogenesis of lung cancer that they negatively or positively regulate gene and protein expression by acting as oncogenes or tumor suppressors.

OBJECTIVE: This article reviewed the current knowledge on the role of miRNAs and their target genes in lung cancer and discussed the potential use of some miRNAs as novel therapeutic agents in lung cancer.

METHOD: First, we collected and summarized all research and review and research articles in databases including Scopus and PubMed. Then, we used related keywords that are important to lung cancer target therapy andtheir diagnostic and prognostic values.

RESULTS: Based on collected articles and research, recognizing critical microRNA and controlling the expression of this microRNA by antagonist oligonucleotides like antagomiRs or anti-miRs and microRNA mimicking will have remarkable role in treating lung cancer.

CONCLUSION: Many researches have shown that combination of chemotherapy plus knockdown or mimicking microRNA are effective and useful in the cancers treatment like lung cancer.