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English Abstract
Journal Article
[Revised 2017 Clinical Diagnostic Criteria for Dementia with Lewy Bodies: Inclusion of REM Sleep Behavior Disorder and Indicative Biomarkers].
Brain and Nerve = Shinkei Kenkyū No Shinpo 2018 August
Although dementia with Lewy bodies (DLB) is the second most common neurodegenerative disorder after Alzheimer disease, its diagnostic sensitivity in clinical practice is sub-optimal. In 2017, the DLB clinical diagnostic criteria were modified to include the additional core feature of REM sleep behavior disorder (RBD) and three new indicative biomarkers. With this revision, clinically probable DLB is represented by two or more core features (fluctuations, parkinsonism, visual hallucinations, or RBD) or by one core feature plus one indicative biomarker (low striatal dopamine transporter uptake, reduced cardiac [<sup>123</sup>I]-metaiodobenzylguanidine uptake, or REM sleep without atonia on polysomnography). Because RBD is an early feature of DLB and often precedes the onset of other core features, a clinical history of RBD enables us to improve the low diagnostic sensitivity of DLB at the early stage of disease progression. Moreover, RBD is an accurate predictor of DLB in terms of the differential diagnosis of dementia based on clinicopathological findings. Increasing the detection rate of RBD with confirmation by indicative biomarkers provides greater diagnostic accuracy of DLB, even in the absence of other core features. This review focuses on the revised DLB clinical diagnostic criteria for identifying patients with probable DLB in clinical practice.
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