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MiR-506-3p inhibits cell proliferation, induces cell cycle arrest and apoptosis in retinoblastoma by directly targeting NEK6.
Cell Biology International 2018 August 7
MicroRNAs (miRs) have been reported to participate in the initiation and progression of retinoblastoma (RB), as the most common primary intraocular malignancy during infancy and childhood worldwide. Recently, miR-506-3p has been reported to be associated with the development of RB, but the expression patterns and biological roles of miR-506-3p in RB have not been studied. In the present study, we found that miR-506-3p was significantly down-regulated in RB tissues and cell lines. Dual-luciferase reporter assay showed that miR-506-3p directly targeted mitosis Gene A (NIMA)-related kinase 6 (NEK6) in RB cells. Enhanced expression of miR-506-3p significantly suppressed cell proliferation, induced G0/G1 cell cycle phase arrest and apoptosis in RB cells, which were attenuated by NEK6 overexpression using MTT assay, colony formation and Flow cytometry analysis. Overall, our results reveal that miR-506-3p functions as a potential tumor suppressor in RB by directly targeting NEK6, suggesting that miR-506-3p may serve as novel therapeutic target for RB patients.
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