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Endoglin targeting in colorectal tumor microenvironment.
Clinical Cancer Research 2018 August 4
On endothelial cells, the TGFβ/BMP-9 co-receptor endoglin emerged as a promising anti-angiogenic target in colorectal cancer (CRC). Its promiscuous expression in cancer associated fibroblasts (CAFs) emerges to facilitate metastasis. The multi-target impact of neutralizing endoglin may offer added benefit in controlling CRC.
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