We have located links that may give you full text access.
First report of bioactive sterols from the muricid gastropod Chicoreus ramosus.
Steroids 2018 September
Two unusual △5 sterols with unprecedented skeletons were isolated from the organic extract of muricid gastropod Chicoreus ramosus collected off the Gulf of Mannar Coast. This is the first report of isolation of bioactive sterols endowed with anti-inflammatory potentials from this species. The compounds were characterized as (5Z)-24a-homo-cholesta-5,24a1 (24a2 ) dien-3β-ol (1) and 27(25 → 23)-abeo-(5Z)-3β-hydroxy-24-isopropyl cholesteno-26,23-lactone (2) by the interpretation of a series of spectroscopic techniques involving two-dimensional nuclear magnetic resonance and mass spectral data. The compound 1 is unusual in that it has an ethylene attachment stemming from the additional methylene group at the 24a position of the steroid side chain, whereas compound 2 has a unique side chain bearing a γ-valerolactone ring. The △5 sterol bearing ethylene group (1) displayed comparatively better antidiabetic activity as characterized by inhibitory effects towards α-amylase and α-glucosidase enzymes (IC50 1.97 mM and 1.78 mM, respectively), whereas the cholestenolactone analogue (2) manifested higher anti-inflammatory activity (IC50 1.42 mM) as determined by in vitro 5-lipoxygenase inhibitory potential. Structure-activity correlation study showed that the biological activities of the studied sterols were directly related to their electronic properties. The homosterol (1) exhibiting improved antidiabetic properties showed higher lipophilic character coupled with lesser steric restrictions.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app