[Fragility Fractures in Hemodialysis Patients. Abnormal bone material characteristics of dialysis patients.]

The relationship between renal dysfunction and bone fragility is well known. Bone fragility, which is associated with an increased risk of bone fracture, affects quality of life and prognosis in patients with chronic kidney disease(CKD). The bone of patients with CKD is more fragile than the risk estimated by measurement of bone mineral density. Bone quality, which is defined by many factors including bone turnover, microarchitecture, collagen crosslinking, and matrix composition, is considered to be major cause of bone fragility of the patients with CKD. In this article, we will describe the bone quality of dialysis patients with CKD as representatives of patients with CKD.