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Clinical Trial
Journal Article
Effects of a single intravenous bolus injection of alfaxalone on canine splenic volume as determined by computed tomography.
Canadian Journal of Veterinary Research 2018 July
The purpose of this study was to evaluate the effects of a single intravenous dose of alfaxalone on canine splenic volume. In 6 adult beagle dogs the splenic volume [mean ± standard error (SE)] was determined by computed tomography to be 0.17 ± 0.02 L before alfaxalone administration and 0.24 ± 0.02 L ( P = 0.0091) and 0.23 ± 0.02 L ( P = 0.0268) 15 and 30 min, respectively, after alfaxalone administration. Hematocrits (mean ± SE) obtained at the same times were, respectively, 46.3% ± 1.3%, 40.6% ± 1.3% ( P = 0.0015), and 41.7% ± 1.3% ( P = 0.0057). In conclusion, alfaxalone caused relaxation of the canine splenic capsule and an increase in the splenic volume, along with a decrease in the hematocrit in these dogs.
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