Compound Heterozygosity for Hb Adana (HBA2: c.179G>A) and the -α 3.7 /αα Thalassemia Deletion in Greece: Clinical Phenotype and Genetic Counseling.

Hb Adana (HBA2: c.179G>A) is found worldwide but is extremely rare and carriers are asymptomatic, with red cell indices similar to α+ -thalassemia (α+ -thal) carriers. First line screening tests are unable to detect the unstable hemoglobin (Hb). Coinheritance with the α-thal (-α3.7 ) deletion is herein presented and the challenges involving genetic counseling of couples carrying the mutations are discussed.