We have located links that may give you full text access.
Journal Article
Review
Targeting the integrin interactome in human disease.
Current Opinion in Cell Biology 2018 December
Integrins comprise one of the most important families of cell-cell or cell-matrix adhesion receptors. Integrin interaction with their extracellular ligands is tunable by microenvironment signals, such as chemokines and growth factors, which modulate their interaction with other transmembrane proteins and cytoplasmic interactors. Integrins are important in different disease contexts, particularly inflammatory diseases and cancer. Clinical trials targeting integrins began in the early 2000s, leading to an increasingly clear picture: agents against integrins and their interactome control inflammatory diseases; whereas their efficacy as anti-cancer targets remains dubious. Here, we discuss the success of integrin targeting to treat autoimmunity and its failure in cancer, which is rooted in the plasticity and adaptability of the cancer cell.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app