Non-invasive Treatment Efficacy Evaluation for HIFU Therapy Based on Magneto-Acousto-Electrical Tomography.

OBJECTIVE: As a novel non-invasive modality of oncotherapy or stroke treatment, high intensity focused ultrasound (HIFU) has drawn more and more attention in the past decades. Whereas, real-time temperature monitoring and treatment efficacy evaluation are still the key issues for HIFU therapy.

METHODS: Based on the temperature-conductivity relation of tissues with a sharp conductivity variation of irreversible thermocoagulation at 69°C, a non-invasive method of treatment efficacy evaluation for HIFU ablation using the magneto-acousto-electrical tomography (MAET) technology is theoretically studied. By applying the nonlinear Khokhlov-Zabolotskaya-Kuznetsov equation and Pennes equation, a cylindrical model is established to simulate the distributions of pressure, temperature and conductivity with the consideration of harmonic components.

RESULTS: The MAET signals are simulated to analyze the characteristics of the peak amplitude and the axial interval of the two clusters generated by the conductivity boundary of HIFU ablation.

CONCLUSION: The axial interval can be used as the indictor to evaluate the size of HIFU ablation with the minimum axial width of one wavelength.

SIGNIFICANCE: The favorable results demonstrate the feasibility of real-time treatment efficacy evaluation for HIFU therapy using the MAET technology and suggest potential applications in clinical practice.