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Research Support, Non-U.S. Gov't
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Extracellular vesicles derived from mesenchymal cells: perspective treatment for cutaneous wound healing in pediatrics.

Gloria Pelizzo, Maria Antonietta Avanzini, Antonia Icaro Cornaglia, Annalisa De Silvestri, Melissa Mantelli, Paola Travaglino, Stefania Croce, Piero Romano, Luigi Avolio, Giulio Iacob, Massimo Dominici, Valeria Calcaterra
Regenerative Medicine 2018 June
AIM: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model.

METHODS: Mesenchymal stem cells (MSCs) were in vitro expanded from adipose (ASC) or BM tissues (BM-MSC) of rabbits. EVs were separated from the supernatants of confluent ASC and BM-MSCs. Two skin wounds were induced in each animal and treated with MSC or EV injections. Histological examination was performed postinoculation.

RESULTS: EV-treated wounds exhibited a better restoration compared with the counterpart MSC treatment. ASC-EV-treated wounds were significantly better than BM-EVs (p = 0.036).

CONCLUSION: EV topical inoculation provides restored architecture during cutaneous wound healing and represents a promising solution for regenerative medicine in children.

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