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A Micelle-Enhanced Spectrofluorimetric Determination of Pirfenidone: Application to Content Uniformity Testing and Human Urine.
Journal of Fluorescence 2018 July
The present manuscript gives a detailed account of highly selective, validated and sensitive method for quantification of pirfenidone in its pharmaceutical dosage forms and spiked human urine. The developed method is relied on the systematic study of the fluorescence action of Pirfenidone in Tween - 80 micellar medium. The Pirfenidone exhibits strong fluorescence at λem 396 nm upon excitation at λex 318 nm in Tween -80 medium. The fluorescence - concentration plot was linear over concentration range of 0.5 - 5 μg/mL. There was greater extent (1.02 fold) of enhancement in fluorescence intensity in presence of tween - 80 with very low limit of detection and quantitation of 0.04 μg/mL and 0.11 μg/mL respectively. The application of developed methodology is successfully applied to content uniformity testing and spiked human urine. The proposed study was successfully applied for analysis of pirfenidone in commercially available pharmaceutical formulations.
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