Experimental morphologic study of reparative processes in erosive lesions of the oral mucosa.

The goal of this preclinical study was to substantiate the effectiveness of using autologous platelet-rich plasma (PRP) to heal erosive lesions in the oral cavity. This study employed analyses of qualitative and semiquantitative morphologic parameters, including histologic assessment of biopsy specimens. The most favorable results were observed in a group of 16 dogs receiving 2-mL injections of autologous PRP 3 times: day 1 of the experiment and after 7 and 14 days of observation; in this group, no traces of inflammatory symptoms were found at the end of the observation period (14 days). At the end of the same time period, a control group of 16 dogs receiving conventional therapy-which consisted of twice daily applications of an anesthetic agent, proteolytic enzymes, an antiseptic agent, and a wound healing preparation-exhibited signs of nonspecific chronic inflammation in certain zones of the oral mucosa. These results suggest that autologous PRP may be useful in the treatment of various inflammatory disorders in the maxillofacial area.