Add like
Add dislike
Add to saved papers

Transcriptome-wide survey, gene expression profiling and exogenous chemical-induced transcriptional responses of cytochrome P450 superfamily genes in migratory locust (Locusta migratoria).

Cytochrome P450 monooxygenases (CYPs) belong to a large superfamily of heme-containing enzymes catalyzing at least 60 different types of chemically distinct reactions. Insect CYPs play key roles in biotransformation of insecticides and plant chemicals, and are implicated in insecticide resistance and insect adaptation to their host plants. Insect CYPs are well studied in model insects, but little is known about the CYP superfamily in paurometabolous insects. We employed Illumina sequencing technology to identify 71 partial and 78 full-length open reading frames (ORFs) of LmCYP genes from the migratory locust (Locusta migratoria), one of the most destructive paurometabolous insect pests in the world. Seventy-eight LmCYPs with complete ORFs were formally named and classified into 19 families and 43 subfamilies. The majority of LmCYPs were mainly expressed in nymphal and adult stages, but LmCYP expression varied widely among thirteen different tissues examined. Regulatory elements were predicted in the promoter regions of LmCYP genes, and subsequent exposure of locusts to 12 different exogenous chemicals showed that 2-tridecanone and xanthotoxin were the most effective at increasing LmCYP expression. Our results represent the first transcriptome-wide analysis of the LmCYP superfamily from migratory locust, and provide a foundation for understanding the physiological functions, functional diversity, evolution, and regulatory mechanisms controlling the expression of the CYP gene superfamily in the locust.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app