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EVALUATION STUDIES
JOURNAL ARTICLE
Evaluation of Antibacterial and Anticancer Activities of the Medicinal Fungus Ophiocordyceps sobolifera (Ascomycetes) from Thailand.
Eleven strains of an entomopathogenic fungus, isolated and identified as Ophiocordyceps sobolifera, were screened for activity against 5 strains of Gram-negative and 5 strains of Gram-positive bacteria. Four of the isolates, Cod-KK1634, Cod-KK1643, Cod-KS1601, and Cod-SN1626, had activity against the test strains of Grampositive bacteria. Of these 4 extracts, the Cod-KK1643 extract had the lowest minimum inhibitory and bactericidal concentrations. The Cod-KK1643 extract exhibited both concentration- and time-dependent bactericidal activity. Moreover, the Cod-KK1643 extract induced morphological alterations in bacterial cells, including decreased cell size, a crushed appearance, and cell lysis. It is surprising to note that the extracts also inhibited MCF-7 cell proliferation, with a half-maximal inhibitory concentration of 47.09 ± 33.64 mg/mL after 72 hours. The extracts also inhibited MCF-7 cell migration, with the lowest percentage of relative closure achieved with Cod-KK1643. These findings represent what is to our knowledge the first information on the activities of O. sobolifera mycelial extracts against bacteria and the human breast cancer MCF-7 cell line.
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