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A20 and ABIN-1 team up against intestinal epithelial cell death.
Journal of Experimental Medicine 2018 July 3
A20 and its binding partner ABIN-1 are genetically linked to inflammatory diseases. In this issue of JEM , Kattah et al. (https://doi.org/10.1084/jem.20180198) demonstrate that simultaneous deletion in a mouse model leads to instantaneous cell death in the intestinal epithelium and mortality.
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