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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication.
Vaccine 2018 July 17
Cellular proteins that support influenza virus infection represent potential therapeutic targets. Cytoplasmic egress intermediates of influenza A/WSN/33 were isolated and shown to be associated with the cellular enzymes peroxiredoxins-1 (Prdx-1) during glycerol gradient fractionation. Prdx-1 also co-localizes with influenza NP at the cell periphery late in infection. Knock-down or knockout of Prdx-1 expression inhibit influenza A replication. Inhibition of replication is not correlated with defects in initiation of infection or mRNA expression, but is correlated with inhibition of accumulation of viral proteins and vRNAs.
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