Chemical constituents of Curcuma kwangsiensis and their antimigratory activities in RKO cells.

Two new sesquiterpenoids, curkwangsien A-B (1-2), and seven known compounds (3-9) were isolated from rhizomes of Curcuma kwangsiensis. Their structures were elucidated by spectroscopic analysis, and the absolute configurations of compounds 1-2 were determined by the quantum chemical ECD calculations. Compounds 3-9 are firstly reported from this plant. In the in vitro assays, compound 3 was found to inhibit human colon cancer RKO cell migration in time-dependent manner.