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Post-pancreatitis diabetes mellitus and gastroparesis: driven together?

Post-pancreatitis diabetes mellitus (PPDM) is a sub-type of diabetes of the exocrine pancreas that develops after acute or chronic inflammation of the pancreas. While pro-inflammatory mileu, glucose metabolism, and lipid metabolism in PPDM have been investigated, little is known about gastrointestinal function in post-pancreatitis setting. This article overviews studies on epidemiology and impact of gastroparesis in the setting of type 1 and type 2 diabetes, with a view to estimating the possible burden of gastrointestinal dysfunction in PPDM. Further, the usefulness of quantifying gastrointestinal dysmotility is discussed. The gastroparesis cardinal symptom index has emerged as a standardised gastrointestinal dysmotility endpoint and its use in individuals after pancreatitis is justified.

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