The Toxic Effect of Lanthanum on Planaria Is Mediated by a Variety of Ion Channels.

The effect of toxic concentrations of La3+ on the Ca, K, Na, Mg, and Cl channels of planaria was investigated through the use of various agonists and antagonists to those channels. It was demonstrated that La exerts its toxic effects through L-type, but not T-type, Ca channels. La also demonstrated activity at Na, K, Mg, and Cl channels, but, these effects were most likely mediated by other effects of La on Ca activity. However, these interactions appear to be very complex and confounded by oxidative stresses. The study also introduces a planaria stress scale which allows the effects of toxic substances to be examined on a continuum.