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Clinical significance of CCR7 + CD8 + T cells in kidney transplant recipients with allograft rejection.

Scientific Reports 2018 June 12
The regulatory function of CCR7+ CD8+ T cells against effector T-cells involved in T-cell mediated rejection (TCMR) in kidney transplant recipients was investigated. In vitro experiments explored the ability of CCR7+ CD8+ T cells to suppress T-cell proliferation under T-cell activation conditions or during coculture with human renal proximal tubular epithelial cells (HRPTEpiC). In an ex vivo experiment, the proportion of CCR7+ /CD8+ , FOXP3+ /CCR7+ CD8+ T and effector T-cell subsets were compared between the normal biopsy control (NC, n = 17) and TCMR group (n = 17). The CCR7+ CD8+ T cells significantly suppressed the proliferation of CD4+ T cells and significantly decreased the proportion of IFN-γ+ and IL-17+ /CD4+ T cells and inflammatory cytokine levels (all p < 0.05). After coculturing with HRPTEpiC, CCR7+ CD8+ T cells also suppressed T-cell differentiation into IL-2+ , IFN-γ+ , and IL-17+ /CD4+ T cells (all p < 0.05). The TCMR group had significantly fewer CCR7+ /CD8+ and FOXP3+ /CCR7+ CD8+ T in comparison with the NC group, but the proportions of all three effector T-cell subsets were increased in the TCMR group (all p < 0.05). The proportion of CCR7+ /CD8+ T was inversely correlated with those of effector T-cell subsets. The results indicate that CCR7+ CD8+ T cells may regulate effector T-cells involved in TCMR in an in vitro and in an ex vivo transplant model.

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