[Analysis of clinical data, esophageal motility and reflux characteristics in patients with non-erosive reflux disease(NERD) and reflux esophagitis(RE)].

Objective: To compare the clinical data, esophageal motility and reflux characteristic in patients with non-erosive reflux disease (NERD) and reflux esophagitis (RE). Methods: A total of 167 patients of NERD were enrolled in the study[60 males, 107 females, mean age(44.1±13.4) years old], and 151 patients of RE were enrolled [74 males, 77 females, mean age(46.5±9.9) years old]. All patients were surveyed by questionnaires to investigate the clinical data. All patients accepted the esophageal highresolution manometry and 24 hours pH+ impedance monitoring to investigate the esophageal motility and reflux characteristic. Results: The proportion of female patients in group NERD was significantly higher than that in group RE(60/107 vs 74/77, P =0.049). The reflux symptom scores and the proportion of reflux in group NERD were significantly lower than those in group RE[(4.5±2.4) vs (5.6±2.1), 44.91% vs 64.24%, P <0.05). The Demeester score of group NERD was significantly lower than that of group RE[12.54(1.60, 10.80) vs 17.31(3.40, 16.64), P =0.044]. The proportion of Demeester scores positive patients in group NERD was significantly lower than that in group RE(15.1% vs 23.8%, P =0.018). The number of acid reflux in group NERD was significantly lower than that in group RE[17.49(3.00, 22.22) vs 21.69(4.00, 30.00), P =0.042]. Conclusions: There are more female patients in group NERD. The reflux symptoms of the group NERD are less serious than those of group RE.RE patients have more acid reflux events. There is no significant difference in the esophageal motility between the two groups.