[Features of local immunity in local inflammatory reactions in pregnant, depending on the implementation of intrauterine infection].

OBJECTIVE: Introduction: Vaginal protective systems function independently of other systemic mechanisms and impairments of local immune mechanisms of the vaginal mucosa are the cause of infectious disorders of the reproductive system The aim: To assess characteristics of local immunity in local inflammatory reactions in pregnant, depending on the implementation of intrauterine infection.

PATIENTS AND METHODS: Materials and methods: The study comprised Group 1 of pregnant women with the presence of bacterial infections with and without implementation of IUI, Group 2 with the presence of viral infections with and without implementation of IUI, Group 3 with the presence of infections of combined polyetiological structure with and without implementation of IUI and control group included pregnant women with physiological pregnancy. The study implied evaluation of the number of leukocytes in vaginal contents, concentration of IgA, IgM, IgG, sIgA, concentration of cytokines-IL-1 β , IL-6, IL-10, TNF- α in vaginal swabs.

RESULTS: Results: Women with the presence of an infectious process without its implementation, regardless of the etiologic factor, were found to have more expressed inflammatory reactions. In the presence of a viral infection, changes in the humoral link of local immunity were less expressed. In Group 1 without implementation of IUI, the concentration of IL-1 β was (73.68 ± 10.23) pg / ml, IL-6 was (53.3 ± 6.8) pg / ml. In Group 2 with implementation of IUI, concentration of IL-10 was (26.72 ± 4.35) pg / ml. In Group 2 without implementation of IUI, the content of TNF-α was (575.25 ± 69.03) pg / ml.

CONCLUSION: Conclusions: The study showed the differences between the groups of pregnant women with different outcome of IUI in the content of proinflammatory and anti-inflammatory cytokines.