Abnormal regions in functional connectivity of chronic schizophrenia.

OBJECTIVES: Schizophrenia is a predominant product of pathological alterations distributed throughout interconnected neural systems. Functional connections (FCs) methodology is an effective lever to investigate macroscopic neural activity patterns underlying critical aspects of cognition and behavior. However, region properties of brain architecture have been less investigated by special markers of dynamical graph in general mental disorders.

METHODS: Embracing the eigenvector centrality in holism significance, our important process is to uncover noticeable edges and regions with antagonistic stance between morbid and normal FCs of 67 healthy controls (HCs) and 53 chronic schizophrenia patients (SZs).

RESULTS: Results suggest that, there are twelve abnormal edges with significant P-value of FCs weight, such as lingual gyrus L versus cuneus L, thalamus L versus middle frontal gyrus R, superior temporal gyrus R versus thalamus R. Importantly, SZs' superior temporal gyrus R, parahippocampal gyrus L and parahippocampal gyrus R are endowed with different eigenvector centrality scores. Concludes: Consistent with SZs' positive symptoms of hallucinations, and negative symptoms of thinking impairment, it can be infer that the functional separation and integration are destroyed in schizophrenia. Thought the strict contrastive study, it is worth stressing that eigenvector centrality is a meaningful biological marker to excavating schizophrenic psychopathology.