We have located links that may give you full text access.
CASE REPORTS
JOURNAL ARTICLE
Coexistence of myasthenia gravis and Lambert-Eaton myasthenic syndrome in a small cell lung cancer patient: A case report.
Medicine (Baltimore) 2018 June
RATIONALE: Myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) are both neuromuscular junction diseases, and some controversy exists whether the 2 diseases occur at the same time.
PATIENT CONCERNS: We report a case that a patient with presentation of acetylcholine receptor (AChR) antibody positive MG and LEMS associated with small cell lung cancer (SCLC).
DIAGNOSES: The patient firstly suffered from fluctuant symptoms, including slurred speech, double eyelid ptosis, and weakness of limbs. His clinical characteristics were consistent with the diagnosis of MG and were effective with the treatment of pyridostigmine bromide and corticosteroids. After 8 months, the performance of repeated electrical stimulation suggested presynaptic lesion, which supported the patient with LEMS. After further examination, malignant tumors were found in the liver and right lung, and the pathology proved small cell carcinoma.
INTERVENTIONS: His clinical characteristics were effective with the treatment of pyridostigmine bromide and corticosteroids. Right hilar lesion and multiple metastatic tumors in liver shrunk after chemotherapy.
OUTCOMES: The patient's condition improved gradually. He was followed up for 17 months without tumor progression.
LESSONS: The case report illustrates that MG and LEMS may be coexisted in the same patient. In MG and LEMS, clinicians should consider the possibility of malignant tumors as early detection and treatment may significantly improve the patient's prognosis.
PATIENT CONCERNS: We report a case that a patient with presentation of acetylcholine receptor (AChR) antibody positive MG and LEMS associated with small cell lung cancer (SCLC).
DIAGNOSES: The patient firstly suffered from fluctuant symptoms, including slurred speech, double eyelid ptosis, and weakness of limbs. His clinical characteristics were consistent with the diagnosis of MG and were effective with the treatment of pyridostigmine bromide and corticosteroids. After 8 months, the performance of repeated electrical stimulation suggested presynaptic lesion, which supported the patient with LEMS. After further examination, malignant tumors were found in the liver and right lung, and the pathology proved small cell carcinoma.
INTERVENTIONS: His clinical characteristics were effective with the treatment of pyridostigmine bromide and corticosteroids. Right hilar lesion and multiple metastatic tumors in liver shrunk after chemotherapy.
OUTCOMES: The patient's condition improved gradually. He was followed up for 17 months without tumor progression.
LESSONS: The case report illustrates that MG and LEMS may be coexisted in the same patient. In MG and LEMS, clinicians should consider the possibility of malignant tumors as early detection and treatment may significantly improve the patient's prognosis.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app