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Cascade Reaction by Chemo- and Biocatalytic Approaches to Obtain Chiral Hydroxy Ketones and anti 1,3-Diols.
ChemistryOpen 2018 May
A chemo- and biocatalytic cascade approach was applied for the stereoselective synthesis of hydroxy ketones and the corresponding 1,3-diols. A new class of tridentate N,N,O ligands was used with copper(II) complexes for the asymmetric β-borylation of α,β-unsaturated compounds. The complex containing ligand L5 emerged as the best performer, and it gave the organoborane derivatives with good ee values. The corresponding keto-alcohol compounds were then bioreduced by yeasts. The biotransformation set up with Rhodotorula rubra allowed ( R )-keto-alcohols and ( S , S )-diols to be obtained with up to 99 % ee and up to 99 % de in favor of the anti enantiomers.
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