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Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.
Bioorganic & Medicinal Chemistry Letters 2018 August 2
Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.
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