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Long-Distance Relationships: Suppression of Repeat-Mediated Deletions.
Trends in Genetics : TIG 2018 August
The high proportion of repetitive DNA sequences in the human genome provides tremendous opportunities for DNA rearrangements between non-allelic repetitive elements. The genome must use multiple competing and collaborating repair mechanisms to minimize these types of DNA rearrangements, some of which fail in cancer cells where DNA repair pathways are suppressed.
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