[The expression of IL-22 in nasal polyps tissues].

Objective: To analyze the expression of IL-22 in nasal polyps and the expression of Th22 cells. Method: The concentrations of IL-22 in nasal polyps were determined by ELISA. The mononuclear cells infiltrated in nasal polyps were separated and flow cytometry was used to analyze the expression of IL-22 in CD4+ T cells and the counts of Th22 cells. Result: Compared with the control group, the expression of IL-22 in nasal polyps did not change significantly, however the expression of IL-22 in CD4+ T cells increased. Furthermore the number of Th22 cells in the tissue increased significantly. Conclusion: The expression of Th22 cells in nasal polyps is significantly increased, which may play an important role in local chronic inflammatory mucosal immunity.