[An immunohistochemical study of CTHRC1,Vimentin,E-cadherin expression in papillary thyroid carcinoma].

Objective: To investigate the expression and significance of CTHRC1 in patients with papillary thyroid cancinoma. Method: We collected 63 specimens of papillary thyroid carcinoma tissue with 36 specimens of the adjacent normal thyroid tissue and 23 specimens of thyroid nodular goiter. The expressions of CTHRC1 protein in these tissues were detected by immunohistochemical staining. The correlations between the expressions of CTHRC1 with clinicopathologic features,E-cadherin and Vimentin expression were analyzed. Result: CTHRC1 protein expression levels in papillary thyroid carcinoma tissue were significantly higher than those in adjacent normal thyroid tissue and benign disease( P <0.01);CTHRC1 expression was significantly correlated with lymph node metastases( P <0.05). Moreover,CTHRC1 expression was correlated with the expression of E-cadherin and Vimentin( P <0.01). Conclusion: CTHRC1 is related with the occurrence and miligant transformation of papillary thyroid cancinoma. We speculated that CTHRC1 might play a role in the epithelial-mesenchymal transition of papillary thyroid cancinoma.