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Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates To Overcome Cancer Resistance.

Gaia Fumagalli, Giulia Giorgi, Máté Vágvölgyi, Eleonora Colombo, Michael S Christodoulou, Veronica Collico, Davide Prosperi, Franco Dosio, Attila Hunyadi, Monica Montopoli, Mariafrancesca Hyeraci, Alessandra Silvani, Giordano Lesma, Lisa Dalla Via, Daniele Passarella
ACS Medicinal Chemistry Letters 2018 May 11
Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The in vitro cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested.

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