We have located links that may give you full text access.
JOURNAL ARTICLE
REVIEW
Counting on Death - Quantitative aspects of Bcl-2 family regulation.
FEBS Journal 2018 May 24
The Bcl-2 protein family members critically regulate mitochondrial outer membrane permeabilization (MOMP), a point-of-no-return in the intrinsic and extrinsic apoptosis pathways. The common view on qualitative interaction and activation patterns of the three subclasses, the BH3-only proteins, prosurvivals, and effectors, is static and currently being revolutionized by an emerging understanding of the complex dynamic equilibria that govern cellular fate. Recent experimental evidence on protein associations with the mitochondrial outer membrane, retrotranslocation to the cytosol, and differential binding affinities in aqueous and membranous environments instigate the development of a revised model of Bcl-2 family interplay. Likely, the dynamic processes and their respective timescales need to be taken into account to authentically understand and, by extension, to generate reliable predictions on cellular decision-making. Here, we review the quantitative aspects of Bcl-2 family-regulated MOMP. In particular, we discuss affinity binding constants of protein-protein associations and velocities of post-translational modifications, membrane (retro-) translocations, and effector oligomerization. Moreover, we provide insights into how these kinetic and network information enable systems biological approaches, further enhancing our understanding of the complex molecular mechanisms governing MOMP.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app